Avelumab in Unresectable/Metastatic, Progressive, Poorly Differentiated, Grade 3 Neuroendocrine Carcinomas (NECs) Abstract #2940

Introduction: Poorly differentiated, G3 NECs are associated with poor outcomes and have no effective treatment options apart from cytotoxic chemotherapy.
Aim(s): To investigate the efficacy of Avelumab, an anti-PD-L1 monoclonal antibody, in poorly differentiated, G3 NECs.
Materials and methods: The NET001 study (NCT03278405) is a single center, phase IIA study of Avelumab, (10mg/kg/IV every 2 weeks for a period of 52 weeks) in pts with poorly differentiated, WHO 2010 G3 NECs, from a gastrointestinal (GI) or lung source, who have progressed on a maximum of 2 lines of prior therapy.. The primary endpoint was ORR by RECIST v1.1; secondary endpoints included mPFS, mOS, DCR at 6 months, and toxicity.
Conference: 17th Annual ENETS Conference (2020)
Category: Medical treatment - Targeted therapies
Presenting Author: MD, PhD Victor Rodriguez-Freixinos

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#920 High Grade (G3) Neuroendocrine Neoplasms Should Be Further Classified According to Morphological Differentiation
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#1666 Prognosis and Incidence in Pancreatic and Gastrointestinal Neuroendocrine Neoplasms with Emphasis on “NET G3”: An Analysis of 198 Cases from Japan
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Keywords: NET G3, GEP-NEN, GI-NET
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