Cerebellar and hypothalamic regulation of vestibular compensation after unilateral labyrinthectomy in rat

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Introduction: The mechanisms of inhibitory regulation of neuronal activity of the vestibular system in health and in the vestibular compensation (VC) occurred with participation of the cerebellum, while non-cerebellar pathways are essential in restoring the stability of visual orientation during movement.

Aim(s): We investigated manifestations of the post stimulus excitatory and inhibitory activity of the Deiters’ neurons in response to high-frequency stimulation of I-V lobules of the cerebellar cortex. Post stimulus activity appeared in the form of tetanic potentiation and depression, followed by post tetanic potentiation and depression.

Materials and methods: In Deiters’ neurons to HFS of the cerebellar anterior cortex were predominantly revealed TD in intact rats, more pronounced at 100 Hz. On the third day after the unilateral labyrinthectomy, even to stimulation of the cerebellum by 50 Hz observed TD in Deiters’ neurons similar to those in intact rats at 100 Hz, but as a rule twice better expressed and accompanied by PTD and PTP.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Manukyan L

Authors: Manukyan L,

Keywords: Cerebellar, electrophysiology,