Chromogranin A is a sensitive marker for detection of recurrence in neuroendocrine tumors

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Introduction: The chromogranin family is a family of large acidic proteins which are expressed in neuroendocrine cells. There are several members in this family (Chromogranin A, B (CgA and CgB) and the secretogranins). Here, we show that CgA is an excellent marker to detect recurrence in neuroendocrine tumors.

Aim(s): The aim of this study was to identify which method is the most sensitive to detect recurrence in carcinoid tumors.

Materials and methods: A total of 56 patients with radically operated small intestinal carcinoid tumors were examined using biomarkers (U-5HIAA and CgA) and radiology (CT, US, Octreoscan and 5-HTP-PET) techniques. Patients were monitored every 3-6 months.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author:

Authors: Tiensuu Janson E, Welin S, Eriksson B, Stridsberg M,

Keywords: small intestinal carcinoid, chromogranin A, follow-up,