Comparison of Manual and Automatic Methods of Ki-67 Proliferation Index for Neuroendocrine Tumors: The Development and Validation of a Novel Digital Pathology Tool (Ki-67Counter)

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Introduction: Ki-67 proliferation index is an increasingly important biomarker used to grade neuroendocrine tumors. Manual counting methods are laborious and subject to inter- and intra-observer variability. Digital counting methods hold promise for fast and reproducible indices, however, they are fraught with technical difficulties.

Aim(s): To develop an automated tool, Ki-67Counter, to improve the speed, reproducibility, and accuracy of automatic Ki-67 counting.

Materials and methods: We have created digital Ki-67 slides of 46 biopsy and/or resections of pancreatic and gastrointestinal neuroendocrine tumors from the University of Kentucky.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Neltner J, Su H, Xing F, Rosser J, Cibull M,

Keywords: digital pathology, automated Ki-67 counting, image analysis,