Differential Expression of Markers in a Midgut Carcinoid Tissue Microarray

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Introduction: Molecular mechanisms driving well-differentiated midgut carcinoid (MGC) tumors are not well-established. To pursue higher resolution tumor diagnostics, we studied a panel of markers for their expression in MGC, including: serotonin, FGF2, b-catenin, and E-cadherin, in primary, lymph node, and liver metastases.

Aim(s): To determine the differential expression of multiple tumor markers in an array of MGC specimens.

Materials and methods: A tissue microarray of primary SI-NETs (n=28) and lymph node metastases (LN-mets, n=24) was assessed by immunohistochemistry for expression of serotonin, FGF2, ß-catenin, E-cadherin and cadherin 17.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Liu E, Mikhitarian K, Revetta F, Shi C,

Keywords: midgut carcinoid, immunohistochemistry, markers,