Evaluation of Lysyl Oxidase-Like-2 (LOXL2) Expression by Immunohistochemistry (IHC) in Gastroenteropancreatic Neuroendocrine Tumors (GEP-NET): A Retrospective Analysis and Comparison with PTEN Abstract #966

Introduction: A better understanding of the relationship between the stroma and the cancer cells of this group of malignancies remains a challenge. LOXL2 is an enzyme that contributes to the synthesis and stabilization of the cellular matrix and plays a role in angiogenesis.
Aim(s): To study the prognostic value of LOXL2 expression by IHC.
Materials and methods: One-hundred and fourteen patients (pts) underwent surgery for GEP-NET from 1980 to 2012 at La Paz Hospital. Tissue microarrays (TMAs) were constructed with 109 available formalin-fixed and paraffin embedded samples. The study was approved by an Ethics Committee.
Conference: 11th Annual ENETS Conference (2014)
Category: Biomarkers
Presenting Author: Dr Jorge Barriuso
Keywords: LOXL2, GEP-NET

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