Gastroduodenal ulceration associated with radioembolization for the treatment of liver malignancies, a newly observed complication: Institutional experience and review of the literature

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Introduction: Microsphere radioembolization is a method of delivering radiation therapy directly to tumors, thereby minimizing toxicity to adjacent structures. Despite the relatively high precision of this modality, numerous adverse effects have been recognized. One particularly untoward complication is the development of severe gastroduodenal ulceration.

Aim(s): Since the utilization of this modality in the treatment of primary and metastatic malignancies of the liver continues to rise, we aim to promote awareness of this complication and to advance the understanding of the pathogenesis, incidence, diagnosis, and treatment of this entity.

Materials and methods: Our institutional experience of gastroduodenal ulceration in patients treated with radioembolization was analyzed and the existing literature on the subject was reviewed.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: Michelle K. Kim

Authors: Naymagon S, Warner R, Patel K, Machac J, Weintraub J,

Keywords: gastroduodenal ulcer, radioembolization, Yttrium-90, microsphere embolization,