Mismatch Repair (MMR) Protein Expression is Uncommon in Poorly Differentiated Neuroendocrine Carcinoma Abstract #1845

Introduction: Microsatellite instability (MSI) has been reported to occur in a significant proportion of neuroendocrine carcinoma (NEC) and mixed adenoneuroendocrine carcinomas (MANEC) (11 out of 89 cases, Sahnane et al, ERC 2015). It might be predictive of response to immunotherapy.
Aim(s): To evaluate MMR protein expression by immunohistochemistry (IHC) in a series of consecutive patients with metastatic NEC.
Materials and methods: Fourteen cases of NEC were studied, including 9 gastroenteropancreatic, 2 thoracic, 1 bladder, 1 head-and-neck and 1 from unknown primary. IIHC for MSH2, MSH6, MLH1 and PMS2 was performed on paraffin embedded tissue, prior to therapy and interpreted according to current recommendations. Primaries (n=6) or metastases (n=8) were analyzed.
Conference: 14th Annual ENETS conference 2017 (2017)
Category: Biomarkers
Presenting Author: Dr Julien Hadoux

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