Parathyroid Hormone-Related Peptide (PTHrP) Secretion by Metastatic Gastroenteropancreatic Neuroendocrine Tumors (GEP-NET): Clinical Features, Diagnosis, Management, and Long-Term Follow-Up

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Introduction: There are a few large series of patients with parathyroid hormone (PTH)-related protein (PTHrP) secreting neuroendocrine tumors (NETs) causing severe hypercalcemia.

Aim(s): To analyze the clinical, biochemical, radiological features, response to therapy and survival of patients with PTHrP-secreting NETs.

Materials and methods: Ten patients with PTHrP-secreting GEP-NETs treated between 1986-2013. MEN1 was excluded. Patients were assessed for progressive disease (PD) and response to therapy of hypercalcemia with three parameters: (1) radiological documentation of PD, (2) progression of clinical symptoms, (3) worsening of biochemical markers. Overall survival (OS) was analyzed using a KM curve.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Kamp K, Feelders R, De Rijke Y, Van Nederveen F, Kwekkeboom D,

Keywords: PTH, PTHrP, net, hypercalcemia,