Pasireotide and Octreotide LAR Was an Effective Combination in a Patient with Small Intestinal NET with Hypokalemia and a High Level of VIP

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Introduction: Small Intestinal neuroendocrine tumors (NET) are argentaffin-positive tumors that progress slowly.

Aim(s): We present a case of small intestinal NET secreting high levels of vasoactive intestinal peptide (VIP) causing severe diarrhea and hypokalemia that showed a good clinical and biochemical response to combination therapy with pasireotide and octreotide LAR.

Materials and methods: A 70-year-old woman who underwent surgery for a small intestinal NET in 1991 had slowly deteriorating health during the spring of 2008, with increasing bouts of diarrhea followed by hypokalemia. High levels of circulating VIP were detected, though serotonin levels were normal.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Kozlovacki G, Welin S, Eriksson B, Granberg D, Gaasvik-Blomqvist L,

Keywords: pasireotide, octreotide LAR, small intestinal NET, diarrhea, VIP ,