Perfusion Changes in Liver Metastases (LM) from Pancreatic Neuroendocrine Tumors (PanNETs) during Everolimus (E) Treatment: Update of Perfusion CT (P-CT) Study.

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Introduction: P-CT can evaluate inner perfusional features of primary and metastatic PanNETs; preliminary evidences suggest its potential role in predicting early response to anti-angiogenic therapies. Perfusional modifications induced by E in LM are not completely understood.

Aim(s): To evaluate modifications detected by P-CT in LM from PanNETs during E treatment.

Materials and methods: Seven patients with LM from G1-2 PanNETs were prospectively evaluated. P-CT was performed at baseline (T0), after 2 (T1) and 4 (T2) months of E. Lesion size, blood flow (BF), blood volume (BV), peak enhancement intensity (PEI) and time to peak (TTP) were calculated. Comparison between P-CT features at different time points was performed with 2-tailed unpaired Student’s T test.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: De Robertis R

Authors: Ortolani S, De Robertis R, D'Onofrio M, Cingarlini S, Crosara S,

Keywords: perfusion CT, pancreas neuroendocrine tumor, everolimus,