Somatostatin Analogs (SSA) in Patients with Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia: A Case Series

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Introduction: Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare lung disease associated with proliferation of neuroendocrine cells in the lung. Although typically considered a benign condition, DIPNECH causes chronic, progressive cough and dyspnea. There have been no treatments described in the literature.

Aim(s): To assess changes in symptoms and pulmonary function tests (PFTs) in response to somatostatin analog (SSA) treatment.

Materials and methods: Eighteen patients with DIPNECH were treated with SSAs at the Moffitt and Hadassah Medical Centers. Sixteen of the patients were symptomatic with chronic cough and/or dyspnea prior to treatment. Their charts were reviewed to assess changes in symptoms and PFTs.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Strosberg J

Authors: Byron E, Grozinsky-Glasberg S, Gross D, Strosberg J,

Keywords: DIPNECH, octreotide, lanreotide,