Un Unusual Tumor Association in Acromegaly

#1913

Introduction: Acromegaly is associated with an increased risk for malignancies. Only a case of pseudomyxoma peritonei with ovarian and appendicular sequential tumors in acromegaly was described

Aim(s): We report the case of appendicular adenocarcinoma in acromegaly in progression despite controlled disease

Materials and methods: A 59 years old woman underwent partial neurosurgery in 2006 for invasive GHoma. Pt started treatment with somatostatin analogues and she underwent second neurosurgery in 2008. In 2010 for resistant disease pt was enrolled in PAOLA study with normalization of GH secretion. In January 2015 a left ovarian cyst was found and pt was followed-up with gynecological ultrasound. In September 2016 for increase in size and appearance of a contralateral lesion pt was oophorectomized-hysterectomized. Histological examination showed infiltration of mucinous adenocarcinoma of probably gastrointestinal origin with a neuroendocrine cell line differentiation. Colonoscopy and gastroscopy were negative. Ecoendoscopy-guided biopsy of gastric wall revealed metastasis of mucinous adenocarcinoma

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Bima C, Chiloiro S, Bianchi A, Schinzari G, Inzani F,

Keywords: acromegaly, appendicular tumor,