A Molecular Multi-Transcript Gene Blood Signature Significantly Outperforms Chromogranin A (CgA) in the Detection of Gut Neuroendocrine Tumors (NETs)

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Introduction: A key issue in NET management is the need for a specific and sensitive biomarker to detect disease and assess treatment. CgA is widely utilized but has limitations.

Aim(s): Validate a 51 transcript blood NET signature for the detection of NETs.

Materials and methods: PCR test in 2 independent NET sets (n=115; n=120) and in third prospective, blinded set of 150 NETs and 50 controls. Compare metrics to CgA (DAKO-ELISA).

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Modlin I

Authors: Modlin I, Kidd M, Drozdov I, Alaimo D, Callahan S,

Keywords: biomarker, CgA, NET, PCR,