Angiogenetic Markers as Prognostic Predictors in Neuroendocrine Neoplasms Abstract #3043
Introduction: Neoangiogenesis is crucial for NEN development and metastatization.
Aim(s): To evaluate the role of angiogenetic markers in NEN aggressiveness and prognosis.
Materials and methods: We performed a prospective observational study including 40 patients (pts) with proven NENs and 32 healthy controls (Ctrl) well matched for age, sex, BMI, smoking and comorbidities. Pro-angiogenic factors were measured in serum by ELISA method (soluble sTIE2 and ANG2) and on tissue sections in 10 pts by immunohistochemistry (ANG2, TIE2 and prokineticin peptides-PROKs). Groups were compared using Mann-Witney test.
Conference: 17th Annual ENETS Conference (2020)
Category: Biomarkers
Presenting Author: Giulia Puliani
Authors:
Puliani G, Feola T, Sesti F, Sciarra F, Campolo F, Tarsitano M G, Verrico M, Vennery M A, Lenzi A, Isidori A M, Faggiano A, Giannetta E
Keywords:
biomarkers, prognosis
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