Introduction: Neoangiogenesis is crucial for NEN development and metastatization.
Aim(s): To evaluate the role of angiogenetic markers in NEN aggressiveness and prognosis.
Materials and methods: We performed a prospective observational study including 40 patients (pts) with proven NENs and 32 healthy controls (Ctrl) well matched for age, sex, BMI, smoking and comorbidities. Pro-angiogenic factors were measured in serum by ELISA method (soluble sTIE2 and ANG2) and on tissue sections in 10 pts by immunohistochemistry (ANG2, TIE2 and prokineticin peptides-PROKs). Groups were compared using Mann-Witney test.
Conference: 17th Annual ENETS Conference 2020 (2020)
Presenting Author: Giulia Puliani
, Feola T
, Sesti F
, Sciarra F
, Campolo F
, Tarsitano M G
, Verrico M
, Vennery M A
, Lenzi A
, Isidori A M
, Faggiano A
, Giannetta E
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