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Angiogenetic Markers as Prognostic Predictors in Neuroendocrine Neoplasms


Introduction: Neoangiogenesis is crucial for NEN development and metastatization.

Aim(s): To evaluate the role of angiogenetic markers in NEN aggressiveness and prognosis.

Materials and methods: We performed a prospective observational study including 40 patients (pts) with proven NENs and 32 healthy controls (Ctrl) well matched for age, sex, BMI, smoking and comorbidities. Pro-angiogenic factors were measured in serum by ELISA method (soluble sTIE2 and ANG2) and on tissue sections in 10 pts by immunohistochemistry (ANG2, TIE2 and prokineticin peptides-PROKs). Groups were compared using Mann-Witney test.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Puliani G

Authors: Puliani G, Feola T, Sesti F, Sciarra F, Campolo F,

Keywords: biomarkers, prognosis,

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