CUX1 Mediates Progression of Neuroendocrine Tumors

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Introduction: CUX1 is a key mediator of tumor progression in pancreatic ductal adenocarcinoma (PDAC) and is upregulated during tumorigenesis in PDAC. It contributes to tumor invasion and is resistant to apoptosis and angiogenesis.

Aim(s): To characterize the effects of CUX1 in neuroendocrine tumors (NETs).

Materials and methods: The effect of CUX1 on proliferation/ apoptosis was analysed using knock-down and overexpression strategies in neuroendocrine Bon-1/Ins1-cell-lines. Conditioned medium of CUX1 overexpressing Bon-1/Ins1-cells was collected for functional assays. CUX1 expression in human and murine insulinomas was evaluated using immunohistochemistry (IHC) and quantitative RT-PCR.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Krug S, Kühnemuth B, Griesmann H, Kortenhaus J, Lankat-Buttgereit B,

Keywords: CUX1, angiogenesis ,