Deletions of 11q21-q25 are associated with atypical lung carcinoids and a poor clinical outcome Abstract #65

Introduction: Lung carcinoids comprise a group of smoking-unrelated neuroendocrine tumors, which can be classified in typical (TC) and atypical (AC) carcinoids. Classification is complex and its accuracy to predict disease outcome is variable. In a previous array comparative genomic hybridization (arrayCGH) study, we showed that the average number of chromosomal alterations (≥ 1Mb) was significantly higher in ACs than in TCs (512 v. 226 per tumor) and that the most common region of chromosome loss was 11q21-q25 (Neuroendocrinology 2009;90:136-137).
Aim(s): To collect clinical follow-up data and to correlate them with the array CGH results, as well as with histopathological and additional demographic patient data.
Materials and methods: We collected demographic data, including age at diagnosis, gender, tobacco exposure, and follow-up (time span 1-25 years, mean 114 months) from medical records of 35 patients treated in the abovementioned institutes. The data were statistically analyzed by SPSS using Pearson’s correlations and Kaplan Meier survival curves.
Conference: 7th Annual ENETS Conference (2010)
Category: Basic
Presenting Author: MSc Dorian RA Swarts

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