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Deletions of 11q21-q25 are associated with atypical lung carcinoids and a poor clinical outcome

#65

Introduction: Lung carcinoids comprise a group of smoking-unrelated neuroendocrine tumors, which can be classified in typical (TC) and atypical (AC) carcinoids. Classification is complex and its accuracy to predict disease outcome is variable. In a previous array comparative genomic hybridization (arrayCGH) study, we showed that the average number of chromosomal alterations (≥ 1Mb) was significantly higher in ACs than in TCs (512 v. 226 per tumor) and that the most common region of chromosome loss was 11q21-q25 (Neuroendocrinology 2009;90:136-137).

Aim(s): To collect clinical follow-up data and to correlate them with the array CGH results, as well as with histopathological and additional demographic patient data.

Materials and methods: We collected demographic data, including age at diagnosis, gender, tobacco exposure, and follow-up (time span 1-25 years, mean 114 months) from medical records of 35 patients treated in the abovementioned institutes. The data were statistically analyzed by SPSS using Pearson’s correlations and Kaplan Meier survival curves.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: Swarts D

Authors: Swarts D, Van Suylen R, Dingemans A, De Herder W, De Krijger R,

Keywords: pulmonary carcinoids, array CGH, survival, 11q deletion, prognosis,

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