Abstract Library

#737 Impact of Ki-67 Proliferative Index on Survival in Patients with Typical and Atypical Pulmonary Carcinoids

Introduction: Currently pulmonary carcinoids are separated into typical and atypical tumors based on mitotic count and presence of necrosis, according to the WHO classification. Whereas for GEP NETs the ENETS Guidelines have been incorporated into the WHO classification and grading is based on mitotic counts and Ki-67 index, the use of the Ki-67 index for grading pulmonary carcinoids is still under debate.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: Rudelius M

Authors: Rudelius M, Swarts D, Cleutjens J, Claessen S, Volante M,

Keywords: pulmonary carcinoids, Ki-67, MIB-1, classification,

#654 Identification of Signaling Pathways Involved in Lung Carcinoid Progression Using Gene Expression Profiling

Introduction: Lung carcinoids are well-differentiated neuroendocrine tumors (NETs) usually associated with a favorable prognosis. Mechanisms underlying progression are poorly understood.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Swarts D, Van Neste L, Henfling M, Eijkenboom I, Van Velthuysen M,

Keywords: bronchial carcinoids, cDNA microarray, chromosomal passenger complex, immunohistochemistry, progression,

#653 Interobserver Variability of Pulmonary Carcinoids

Introduction: Lung carcinoids are neuroendocrine tumors histopathologically classified into typical (TC; no necrosis, <2 mitoses/2 mm2) and atypical (AC; necrosis or 2-10 mitoses/2 mm2). Identification of mitoses may be hampered by the presence of apoptotic cells, and reported prediction of prognosis based on histopathology varies, especially for ACs.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Swarts D, Van Suylen R, Den Bakker M, Van Oosterhout M, Thunnissen E,

Keywords: lung carcinoids, classification, histopathology, interobserver variation, orthopedia homeobox, MIB-1,

#462 Genome-Wide Expression Profiling Reveals Downregulation of OTP and CD44 and Upregulation of RET as Indicators of Poor Prognosis in Lung Carcinoids

Introduction: Lung carcinoids comprise a heterogeneous group of neuroendocrine tumors. Only few parameters have been identified that correlated with poor disease outcome, including 11q22-q25 deletions. New biomarkers are required to further improve diagnosis and prediction of prognosis.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Swarts D, Van Neste L, Henfling M, Van Suylen R, Volante M,

Keywords: Bronchial carcinoids, cDNA microarray, MEN-2,

#360 High Resolution (Epi)genomic Analysis Comparing Pulmonary Carcinoids with a Favorable and a Poor Disease Outcome

Introduction: Lung carcinoids are a heterogenous group of neuroendocrine tumors. MEN1 mutations and 11q22-q25 deletions have been implied in their tumorigenesis. Very few genome wide and methylation studies have been conducted to further elucidate molecular mechanisms underlying tumorigenesis.

Conference:

Presenting Author:

Authors: Swarts D, Van Neste L, De Hoon J, Van Velthuysen M, Burgers J,

Keywords: Bronchial carcinoids, MIRA, Expression profiling, arrayCGH,