Abstract Library

#360 High Resolution (Epi)genomic Analysis Comparing Pulmonary Carcinoids with a Favorable and a Poor Disease Outcome

Introduction: Lung carcinoids are a heterogenous group of neuroendocrine tumors. MEN1 mutations and 11q22-q25 deletions have been implied in their tumorigenesis. Very few genome wide and methylation studies have been conducted to further elucidate molecular mechanisms underlying tumorigenesis.

Conference:

Presenting Author:

Authors: Swarts D, Van Neste L, De Hoon J, Van Velthuysen M, Burgers J,

Keywords: Bronchial carcinoids, MIRA, Expression profiling, arrayCGH,

#65 Deletions of 11q21-q25 are associated with atypical lung carcinoids and a poor clinical outcome

Introduction: Lung carcinoids comprise a group of smoking-unrelated neuroendocrine tumors, which can be classified in typical (TC) and atypical (AC) carcinoids. Classification is complex and its accuracy to predict disease outcome is variable. In a previous array comparative genomic hybridization (arrayCGH) study, we showed that the average number of chromosomal alterations (≥ 1Mb) was significantly higher in ACs than in TCs (512 v. 226 per tumor) and that the most common region of chromosome loss was 11q21-q25 (Neuroendocrinology 2009;90:136-137).

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: Swarts D

Authors: Swarts D, Van Suylen R, Dingemans A, De Herder W, De Krijger R,

Keywords: pulmonary carcinoids, array CGH, survival, 11q deletion, prognosis,