Identification of Signaling Pathways Involved in Lung Carcinoid Progression Using Gene Expression Profiling

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Introduction: Lung carcinoids are well-differentiated neuroendocrine tumors (NETs) usually associated with a favorable prognosis. Mechanisms underlying progression are poorly understood.

Aim(s): To identify signaling pathways associated with disease progression.

Materials and methods: We compared gene expression profiles of tumors from five patients with a favorable and five with a poor disease outcome. Results were validated using quantitative RT-PCR on 65 carcinoids, in combination with survival analysis. One pathway was further examined using immunohistochemistry on 65 lung NETs.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Swarts D, Van Neste L, Henfling M, Eijkenboom I, Van Velthuysen M,

Keywords: bronchial carcinoids, cDNA microarray, chromosomal passenger complex, immunohistochemistry, progression,