Feasability of a Dosimetry Guided Therapy Planning for Peptide Receptor Radionuclide Therapy with 177Lu-DOTA-Octreotate

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Introduction: The efficacy and safety profile of PRRT can theoretically be optimized by planning each individual patient treatment on the absorbed dose to the critical organs and tumor lesions.

Aim(s): Critical organs were derived from the toxicity in the follow-up after the present 177Lu-DOTA-octreotate therapy with four administrations of 7.4 GBq with dosimetry to decide whether to complete the full therapy without exceeding 23 Gy to the kidneys in 615 patients.

Materials and methods: Acute and late haematological toxicity was evaluated in 325 Dutch patients according to CTC-grading. Kidney dosimetry was performed in 408 out of 615 patients at three time-points after the first administration. Late occurring kidney toxicity was defined by a more than 20% decline per year in creatinine clearance. Creatinine clearance was evaluated in 188 patients with more than one year follow-up.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Krenning E, Erion J, Boesen-de Cock J, Kooij P, Kwekkeboom D,

Keywords: PRRT, dosimetry,