GSK3: A Novel Therapeutic Target in NETs? Abstract #1891

Introduction: GSK3 is a serine/threonine-kinase that plays a critical role in cancer. In neuroendocrine tumours (NETs) GSK3 is regularly overactivated.
Aim(s): In this study, we investigated the effects of the GSK3α/β-inhibitor AR-A014418 alone and in combination with lovastatin, everolimus or 5-fluorouracil (5FU) in human pancreatic (BON1, QGP1) and pulmonary (H727) NET cell lines.
Materials and methods: MTS assay, Western blot analysis, FACS, caspase and migration assays were performed to study cell viability, signalling pathways, apoptosis, cell cycle and migration.
Conference: 14th Annual ENETS conference 2017 (2017)
Category: Medical treatment - Targeted therapies
Presenting Author: Dr. Svenja Nölting

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