Inhibition of Intestinal Neuroendocrine Tumor by a New Marker of Normal Neuroendocrine Cells

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Introduction: Although gastrointestinal neuroendocrine tumors are increasing worldwidely, few treatment options could be chosen

Aim(s): By comparative proteome, we discovered a new protein Xpec was expressed only in normal intestinal tissue, but not in intestinal neuroendocrine tumor (INET), this study will illustrate the role of Xpec in INET.

Materials and methods: Xpec were detected in 30 INET tissues and their adjacent normal controls with immunostain. Subcellular collocation of Xpec with chromogranin A(CGA) or neuron-specific enolase(NSE), markers of gastrointestinal neuroendocrine cells, were determined by immunofluroscence stain. Cell proliferation, cell cycle, expression of related molecules were observed after Lentiviral overexpression or RNAi of Xpec in INET cells, NCI-H716 (low Xpec) or Colo320(high Xpec). Further, Xpec lentivirus was used to treat INET xenografts in nude mice.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Guo Y

Authors: Pan B, Yang W, Zhang T, Guo Y,

Keywords: GEP-NETs, Wnt, marker,