Ki-67 is a Better Prognostic Marker than Mitotic Count in Neuroendocrine Tumors

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Introduction: The recent classification system proposed by ENETS assigns grade by Ki-67 index +/- mitotic count. It has been adopted into routine practice but there is limited data on the relationship between them.

Aim(s): To explore the prognostic value of grading according to Ki-67 and mitotic count in gastroenteropancreatic (GEP) neuroendocrine tumors (NETs).

Materials and methods: Two-hundred and eighty-five NET patients (144 midgut, 141 pancreatic) had their cases reviewed. Ki-67 index and mitotic count were evaluated by an experienced pathologist with expertise in NETs and grade assigned using both indices. Progression-free survival(PFS) and overall survival (OS) from diagnosis were estimated and multivariate analysis performed with Cox regression.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Khan M, El-Khouly F, Toumpanakis C, Meyer T, Caplin M,

Keywords: survival, neuroendocrine tumor, Ki-67, proliferation, biomarker,