M-TORC1 Complex Is Significantly Over-Activated in SDHx-Mutated Paragangliomas

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Introduction: The activation patterns of mTOR pathway in sporadic and hereditary pheochromocytomas (PCC) and paragangliomas (PGL) are poorly recognized.

Aim(s): To test mTOR pathway-related molecules in a series of 178 PCC and 44 PGL, already characterized for the presence of germline mutations in VHL, RET, NF-1, MAX, SDHA, SDHB, SDHC, SDHD and somatic mutations in VHL, RET, HRAS and MAX.

Materials and methods: Cases were included into five TMAs and tested using immunohistochemistry for mTOR and Rictor, and the phosphorylated forms of mTOR, p70S6K, AMPK, AKT, 4E-BP1, S6 and Raptor.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Volante M

Authors: Oudijk L, Papathomas T, De Krijger R, Gimenez-Roqueplo A, Mannelli M,

Keywords: PCC, PGL, mTOR, SDHx,