Abstract Library

#3978 SDHx germline mutation in thymic neuroendocrine tumors

Introduction: Mutation in succinate dehydrogenase complex genes (SDHA, SDHB, SDHC, SDHD) could be found in 10% of hereditary paraganglioma-pheochromocytomas and gastrointestinal stromal tumors. Nearly 25% of thymic neuroendocrine tumors (TNETs) are asscociated with MEN1. TNETs asscociated with SDHx germline mutation have not been reported.

Conference:

Presenting Author: Liang Y

Authors: Liang Y, Chen J,

Keywords: SDHx，thymic neuroendocrine tumor,

#3241 Clinical features and management of paragangliomas in a tertiary university hospital

Introduction: Paragangliomas (PG) are rare neuroendocrine tumors that arise from the extra-adrenal paraganglia. The most frequent location is head and neck PG (HNPG), usually non-functioning tumors. PG present a high rate of genetic susceptibility mainly associated with SDHx mutation. Clinical presentation depends upon catecholamine secretion and tumor location. Surgery remains the standard treatment, although radiotherapy and systemic therapies can be considered for unresectable or metastatic disease.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Damaso S, Lopes Brás R, Paiva R, Macedo D, Fernandes I,

Keywords: paraganglioma, treatment, sdhb gene,

#2788 Favourable Outcome in Patients with Metastatic Pheochromocytomas and Paragangliomas Treated with 177Lu-DOTATATE

Introduction: There is limited previous data on Peptide receptor radiotherapy (PRRT) in pheochromocytoma (PCC) and paraganglioma (PGL).

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Vyakaranam A

Authors: Vyakaranam A, Crona J, Thiis-Evensen E, Hellman P, Norlén O,

Keywords: PRRT, 177Lu-DOTATATE, Pheochromocytoma, Paraganglioma,

#1380 Assessment of the Growth Rate of Paragangliomas Related to SDHx Gene Mutations Using Computed Tomography.

Introduction: SDHx mutations are associated with a lifelong risk of multifocal paragangliomas (PGL), so patients need regular follow-up examinations.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Ćwikła J

Authors: Michałowska I, Peczkowska M, Cwikła J, Michalski W, Wyrwicz L,

Keywords: SDHx mutation, paraganglioma ,

#1131 M-TORC1 Complex Is Significantly Over-Activated in SDHx-Mutated Paragangliomas

Introduction: The activation patterns of mTOR pathway in sporadic and hereditary pheochromocytomas (PCC) and paragangliomas (PGL) are poorly recognized.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Volante M

Authors: Oudijk L, Papathomas T, De Krijger R, Gimenez-Roqueplo A, Mannelli M,

Keywords: PCC, PGL, mTOR, SDHx,