Clinical features and management of paragangliomas in a tertiary university hospital

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Introduction: Paragangliomas (PG) are rare neuroendocrine tumors that arise from the extra-adrenal paraganglia. The most frequent location is head and neck PG (HNPG), usually non-functioning tumors. PG present a high rate of genetic susceptibility mainly associated with SDHx mutation. Clinical presentation depends upon catecholamine secretion and tumor location. Surgery remains the standard treatment, although radiotherapy and systemic therapies can be considered for unresectable or metastatic disease.

Aim(s): Characterize the population of patients with PG regarding clinical characteristics, treatment approaches and outcomes.

Materials and methods: Retrospective unicentric study that includes 9 patients with PG followed at an Oncology Department between January 2015 and May 2020. Clinical details were obtained from clinical files.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Damaso S, Lopes Brás R, Paiva R, Macedo D, Fernandes I,

Keywords: paraganglioma, treatment, sdhb gene,