Metabonomic Profiling: A Novel Approach in Neuroendocrine Neoplasias

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Introduction: There is a substantial unmet need for novel biomarkers for neuroendocrine neoplasms (NEN).

Aim(s): An analytical platform was developed to define a diagnostic metabolic phenotype for NEN.

Materials and methods: Forty-nine patients with NEN were prospectively recruited: 15 small bowel NEN [SBNEN]; 21 pancreatic NEN [PNEN], 13 other NEN. There were 21 healthy controls. Urine samples were subjected to 1H nuclear magnetic resonance spectroscopy on a Bruker Avance III 600 MHz spectrometer. Acquired spectral data were imported into SIMCA-P for supervised and unsupervised multivariate analysis. Selected samples were used for two-dimensional nuclear magnetic resonance spectroscopy (2D-NMR) for metabolite identification in an 800 MHz Bruker Avance II spectrometer.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Jiminez B

Authors: Jimenez B, Drymousis P, Kinross J, Nicholson J, Frilling A,

Keywords: Metabonomics, NEN,