Non-functioning Adrenal Composite Pheochromocytoma-Ganglioneuroma Simultaneous with Subclinical Cushing's Syndrome Due to Contralateral Adrenal Hyperplasia - An Unusual Presentation

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Introduction: “Composite” pheochromocytoma is a rare tumor, consisting of pheochromocytoma and neuroblastic tumors. The definite diagnosis is histological. Subclinical Cushing's syndrome refers to autonomous glucocorticoid production without specific signs and symptoms of Cushing's syndrome.

Aim(s): To present an unusual case of composite pheochromocytoma-ganglioneuroma, simultaneous with subclinical Cushing's syndrome.

Materials and methods: A 53-year old Caucasian female presented with central obesity and hypertension, and no other clinical signs of hypercorticism or of cathecolamine excess. Hormonal evaluation was suggestive of subclinical Cushing's syndrome. Urinary metanephrines were within the normal range. Imaging revealed a right adrenal mass suspicious of malignancy, as well as a left adrenal adenoma. Right adrenalectomy and surgical removal of the left adrenal tumor were performed.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Kiraly A

Authors: Kiraly A, Muntean V, Domsa I, Ghervan C,

Keywords: adrenal, composite, pheochromocytoma, ganglioneuroma, hypercorticism.,