Olfactory Receptor 51E1 is a Potential Novel Tissue Biomarker for the Diagnosis and Prognosis of Small Intestine Neuroendocrine Tumors

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Introduction: Small intestine neuroendocrine tumor (SI-NET) patients get late diagnosis. We reported olfactory receptor 51E1 (OR51E1) as a SI-NET-mRNA marker.

Aim(s): To understand whether, OR51E1 protein may be developed as a novel diagnostic and prognostic marker.

Materials and methods: OR51E1 coding sequence cloning using RNA from human NET cells and patient specimens. QRT-PCR and immunohistochemistry investigated OR51E1 expression. Laser-capture-microdissection (LCM) isolated tumor and normal cells. Immune-fluorescence localized OR51E1 and vescicular-monamine-transporter-1 (VMAT1).

Conference:

Presenting Author:

Authors: Cui T, Tsolakis A, Cunningham J, Li S, Lind T,

Keywords: OR51E1, small-intestine-neuroendocrine-tumors, diagnostic-prognostic tissue biomarker,