Prevalence of Carcinoid Heart Disease in Patients with Disseminated Small Intestinal NET

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Introduction: In patients with small intestinal neuroendocrine tumours (SI-NETs), serotonin may induce fibrosis and lead to carcinoid heart disease (CHD) with right sided valvular dysfunction.

Aim(s): Our aim was to investigate the prevalence of CHD in patients with disseminated SI-NET.

Materials and methods: This was a prospective study of patients with disseminated SI-NETs seen at our outpatient clinic between 2014 -2016. 53 patients were evaluated with 2D and 3D transthoracic echocardiography. Diagnosis was based on assessment of all four valves, and right ventricular size and function. Valve regurgitation and stenosis was quantified according to European Society of Cardiology guidelines. A validated scoring system was used to characterize each affected valve and calculate a carcinoid score.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Groenbaek H

Authors: Dam G, Rasmussen V, Oksjoki R, Villadsen G, Grønbæk H,

Keywords: carcinoid heart disease, SI-NET,