Role of VEGFR-2, P53, P53R2 and Ki-67 Expression in Metastatic Carcinoid Cancer

#321

Introduction: Ki-67 expression is a well-known prognostic factor in neuroendocrine tumors. The role of modified expression of p53, p53R2 and VEGFR2 in this disease’s liver metastases has not been established.

Aim(s): To analyze the impact of the expression of p53, p53R2, VEGFR2 and Ki-67 on the outcomes after resection of neuroendocrine tumor liver metastases.

Materials and methods: A prospectively collected database identified 29 patients surgically treated for neuroendocrine liver metastases at our institution between 1999 and 2010. The expressions of Ki-67 (<1%; = 1%), p53 and p53R2 and VEGFR2 (negative or positive) were determined by immunohistochemical analyses and their impact on survival was established.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Spencer R, Costa W, Salvador H, Diniz A, Cruz C,

Keywords: neuroendocrine tumor, liver metastasis, P53, P53R2, VEGFR2, Ki-67 ,