Sensitivity of Glucagon-Like Peptide-1 Receptor (GLP1-R) SPECT/CT, PET/CT and MRI for the Localization of Benign Insulinomas: Interim Analysis of a Prospective Imaging Efficacy Study

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Introduction: 40 patients (pat.) with positive whipple trias were enrolled (ClinicalTrials.gov, NCT02127541).

Aim(s): The study aim is to compare the detection rate of GLP-1R PET/CT, SPECT/CT and MRI in pat. with suspicion for an insulinoma. We report preliminary results.

Materials and methods: A standardized contrast enhanced 3T MRI was performed. Then pat. received SPECT/CT at 4 and 72h p.i. of 111In-DOTA-exendin-4 and a PET/CT 2,5h p.i. of 68Ga-DOTA-exendin-4 in a randomized cross-over order. 3 independent blinded nuclear medicine physicians and radiologists reviewed the scans. Standard of comparison was the histological diagnosis.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Antwi A, Fani M, Heye T, Nicolas G, Merkle E,

Keywords: insulinoma, GLP-1R,