Significance of Ectopic Lymph Node-Like Structures in Neuroendocrine Tumors of the Small Bowel

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Introduction: The formation of extranodal tertiary lymphoid follicles and lymphoid cell aggregates has been described in nonmalignant conditions including autoimmune diseases and chronic inflammation as well as in cancer. Tumor-induced lymph node-like structures (LLS) participate in the host’s antitumor immune response by driving intratumoral immune cell priming

Aim(s): To evaluate the prognostic relevance and biologic significance of an adaptive immune reaction to small bowel NETs

Materials and methods: Host immune response was evaluated by IHC in 60 well differentiated small bowel NETs. A miRNA microarray analysis was performed to identify a molecular signature of LLS presence

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Cives M, Strosberg J, Simons S, Coppola D,

Keywords: Immune microenvironment,lymph node-like structures,