Introduction: cAMP is implicated in the inhibition or stimulation of proliferation depending on cell type. Although the effects exerted by cAMP were initially attributed to the PKA activation, two cAMP-activated guanine nucleotide exchange (Epac1/2) have been later identified as cAMP targets.
Aim(s): To investigate the cAMP effects in neuroendocrine tumorous cells on cell proliferation and adhesion to determine the role of Epac and PKA in mediating these effects.
Materials and methods: We tested the effects of different cAMP analogs (Epac-selective, PKA-selective, or non selective) on cell proliferation, evaluating also the cyclin D1 and p27 expression, and on cell adhesion, in neuroendocrine primary culture (gastroenteropancreatic-NET and bronchial carcinoid) and in appropriate cell lines (QGP1 and H727).
Conference: 11th Annual ENETS Conference 2014 (2014)
Category: Basic Science - In vitro models, tumor growth, CTCs
Presenting Author: Eleonora Vitali
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