Abstract Library

#894 The Effects of cAMP in Different Neuroendocrine Tumorous Cells: The Role of Epac and PKA in Cell Proliferation and Cell Adhesion

Introduction: cAMP is implicated in the inhibition or stimulation of proliferation depending on cell type. Although the effects exerted by cAMP were initially attributed to the PKA activation, two cAMP-activated guanine nucleotide exchange (Epac1/2) have been later identified as cAMP targets.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Vitali E, Zerbi A, Peverelli E, Mantovani G, Cambiaghi V,

Keywords: cAMP, PKA, EPAC, GEP-NET,

#316 Utilization of Gene Network Graph Topology with Inference Relevance Analysis Delineates G Protein-coupled Receptor Pathways and CREB Targets in Small Intestinal Neuroendocrine Neoplasia

Introduction: Despite an increasing incidence, a paucity of biological information has led to major limitations in identification of plausible therapeutic targets for small intestinal neuroendocrine tumors (SINETs)

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Drozdov I, Kidd M, Svejda B, Gustafsson B, Mane S,

Keywords: CRE, gene network analysis, neuroendocrine tumor, PKA, small intestine, topology, transcription,

#304 Hepatic Neuroendocrine Tumor Metastasis Proliferation is Hepatocyte Regulated Via a 5HT7 Mediated Induction of an IGF 1 and HGF Feedback Loop Mediated by cAMP, PKA-independent pAKT and pCREB

Introduction: Carcinoid serotonin (5-HT) causes local fibrosis but the effect of 5-HT on hepatocytes has not been established. We hypothesized that tumors and hepatocytes form a metastasis-supportive environment.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Svejda B, Kidd M, Lawrence B, Alaimo D, Schimmack S,

Keywords: 5-HT, carcinoid, growth factor, HGF, IGF-I, hepatocyte, liver, proliferation, neuroendocrine tumor,