Abstract Library

#344 Cell Cycle Phase Expression Profile Guided Selection of Proliferative Markers for Well-differentiated Small Intestinal Neuroendocrine Neoplasms

Introduction: Grading of neuroendocrine lesions is often determined by Ki-67 (immunostain), despite limited prognostic ability for this cell cycle marker in well-differentiated tumors (WDNETs) and carcinomas.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Lawrence B, Kidd M, Alaimo D, Svejda B, Drozdov I,

Keywords: biomarker, Ki-67, NALP1, neuroendocrine tumor, PCR, proliferation, survivin, transcript,

#318 The SEER as a Prophet: Epidemiological Analysis as a Harbinger of Evolving Priorities in Gastroenteropancreatic Neuroendocrine Neoplasia

Introduction: Previous epidemiology analysis of tumor registries established that gastroenteropancreatic neuroendocrine neoplasms (GEP-NETs) were both more prevalent, and more malignant, than previously recognized.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Lawrence B, Gustafsson B, Chan A, Svejda B, Kidd M,

Keywords: black, carcinoids, epidemiology, GEP-NET, incidence, pancreas, rectal, SEER, survival, USA,

#316 Utilization of Gene Network Graph Topology with Inference Relevance Analysis Delineates G Protein-coupled Receptor Pathways and CREB Targets in Small Intestinal Neuroendocrine Neoplasia

Introduction: Despite an increasing incidence, a paucity of biological information has led to major limitations in identification of plausible therapeutic targets for small intestinal neuroendocrine tumors (SINETs)

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Drozdov I, Kidd M, Svejda B, Gustafsson B, Mane S,

Keywords: CRE, gene network analysis, neuroendocrine tumor, PKA, small intestine, topology, transcription,

#312 Evidence for the role of miR196a in regulating small intestinal neuroendocrine tumor proliferation and metastasis via HOX/AKT pathway activation

Introduction: MicroRNAs (miRNAs) regulate cell proliferation, differentiation, and apoptosis functioning as tumor suppressor genes but their role in NET proliferation and metastasis has not been fully evaluated.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Kidd M, Lawrence B, Alaimo D, Svejda B, Schimmack S,

Keywords: AKT, carcinoid, HOX, miRNA, metastasis, neuroendocrine tumor, proliferation, small intestine,

#309 The Utility of Alpha Internexin as a Predictive Tissue Biomarker for Proliferation in Gastrointestinal and Pancreatic Neuroendocrine Tumors

Introduction: GEP-NETs are increasing but Ki-67 and CgA provide limited information regarding malignancy. A key unmet need is alternative biomarkers to assess the likelihood of local invasion or metastasis.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Schimmack S, Lawrence B, Svejda B, Fischer L, Schmitz-Winnenthal H,

Keywords: alpha-internexin, biomarker, GEP-NET, INA, Ki-67, malignancy, metastasis, neuroendocrine tumor, PCR,