Abstract Library

#2289 Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Receptor Expression in Patients with Neuroendocrine Neoplasia

Introduction: Targeting the death receptor pathway of apoptosis represents a promising approach for the development of novel cancer therapeutics. TNF-related TRAIL induces apoptosis upon binding to TRAIL receptors 1 and 2 (TRAIL-R1/DR4 and TRAIL-R2/DR5). TRAIL-R3 (DcR1) and TRAIL-R4 (DcR2) have been reported to block TRAIL-mediated apoptosis upon overexpression. Specially agonists for the apoptosis-inducing TRAIL-R1 and TRAIL-R2 are currently tested in clinical trials.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Sättele R, Jann H, Fischer C, Pape U, Schefold J,

Keywords: TRAIL, apoptosis, NENs,

#1736 Slit2-Robo1 Signaling Activates Ras to Suppress Metastasis and Is Associated with Time-To-Progression in Pancreatic Neuroendocrine Tumors

Introduction: Transcriptom analysis revealed that mRNA signatures of distinct metastatic phenotypes in pancreatic NETs (pNETs) exhibit differences in components of the Slit-Robo pathway.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Fischer C, Göhrig A, Körner J, Lombardi M, Welzel M,

Keywords: NET, ras, slit, robo, metastasis, orthotopic,

#1539 Slit-Robo Signaling Links to Ras Activity to Suppress Metastasis and Is Associated with Time-to-Progression in Pancreatic Neuroendocrine Tumors

Introduction: mRNA signatures of distinct metastatic phenotypes of pancreatic NETs (pNETs) exhibit differences in several components of the Slit-Robo axon guidance system.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Fischer C

Authors: Detjen K, Göhrig A, Hilfenhaus G, Körner J, Lombardi M,

Keywords: Slit2, Robo1, pancreatic, NET, pNET, metastasis, mouse model,

#1350 Understanding a Neuroendocrine Tumors’ Impact on Health Systems: A Population-Based Economic Analysis of Patterns of Costs

Introduction: Little is known on resource utilization and health care costs in NET care.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Hallet J

Authors: Hallet J, Law C, Cheung M, Fischer H, Liu N,

Keywords: costs, care patterns,

#803 Analysis of Somatostatin-Receptor 2A (SSTR2A) Immunohistochemistry, RT-qPCR and In-Vivo- PET/CT Data in Patients with Pancreatic Neuroendocrine Neoplasm

Introduction: Ga-68 somatostatin receptor (SSTR) PET/CT is one of the most sensitive imaging methods for pancreatic neuroendocrine tumors.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Kaemmerer D, Wirtz R, Fischer E, Hommann M, Sänger J,

Keywords: molecular imaging, somatostatin receptor, pancreatic tumor,