Slit-Robo Signaling Links to Ras Activity to Suppress Metastasis and Is Associated with Time-to-Progression in Pancreatic Neuroendocrine Tumors

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Introduction: mRNA signatures of distinct metastatic phenotypes of pancreatic NETs (pNETs) exhibit differences in several components of the Slit-Robo axon guidance system.

Aim(s): We aimed at delineating the role of Slit-Robo signaling for tumor progression in pNETs.

Materials and methods: Expression of Slit2 and Robo1 on human pNET tissues was determined by IHC and qPCR. Migration and colony formation as well as metastasis in mice were evaluated as read-outs.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Fischer C

Authors: Detjen K, Göhrig A, Hilfenhaus G, Körner J, Lombardi M,

Keywords: Slit2, Robo1, pancreatic, NET, pNET, metastasis, mouse model,