Abstract Library

#1737 The Role of MAPK-Signalling in Pancreatic Neuroendocrine Cancer

Introduction: Upon diagnosis, 65% of pNET patients suffer from metastatic or locally unresectable disease. The receptor tyrosine kinase inhibitor sunitinib and the mTOR inhibitor everolimus have set precedence for successful targeted therapies in pNET disease. However, response prediction and treatment alternatives still do not meet medical needs. Recent studies revealed mutations in RAS oncogenes in a fraction of tumours, emphasising a potential role of the MAPK pathway as therapeutic target.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Hoffmann J, Corbett L, Detjen K, Thedieck K, Sers C,

Keywords: pancreatic neuroendocrine tumors, MAPK pathway,

#1539 Slit-Robo Signaling Links to Ras Activity to Suppress Metastasis and Is Associated with Time-to-Progression in Pancreatic Neuroendocrine Tumors

Introduction: mRNA signatures of distinct metastatic phenotypes of pancreatic NETs (pNETs) exhibit differences in several components of the Slit-Robo axon guidance system.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Fischer C

Authors: Detjen K, Göhrig A, Hilfenhaus G, Körner J, Lombardi M,

Keywords: Slit2, Robo1, pancreatic, NET, pNET, metastasis, mouse model,

#770 The Axon Guidance Molecules Slit2 and Robo Control Motility and Growth of Pancreatic Neuroendocrine Tumor Cells

Introduction: Dense vascularization and high frequency of metastasis in pancreatic neuroendocrine tumors (pNET) suggest a central role for the interaction of tumor cells and vessels. Slit2 and its receptors Robo1 and Robo4 act as guidance cues in neurogenesis, angiogenesis and epithelial morphogenesis, and hence represent attractive candidate regulators at the tumor cell/stroma interface.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: Fischer C

Authors: Detjen K, Hilfenhaus G, Göhrig A, Körner J, Welzel M,

Keywords: Axon guidance, Slit2, Robo, NET, metastases, motility,

#466 HIF-1a Determines the Metastatic Potential of the GEP-NET Cell Line BON-1

Introduction: Intratumoral hypoxia is a hallmark of solid tumor formation and a negative predictor of patient survival. Adaptation to hypoxia is mainly achieved by the transcription factor HIF-1a, which is upregulated in a diverse range of human and experimental tumors and their metastases. HIF-1a target genes have been implicated in the induction of invasion and metastasis. However, HIF-1a’s tumor-supporting action depends on cell type and microenvironment and the precise role of HIF-1a for the pathogenesis of neuroendocrine tumors (NET) is largely unknown.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Freitag de Molina K, Rohwer N, Detjen K, Wiedenmann B, Cramer T,

Keywords: hypoxia, hif-1a, metastases,