Abstract Library

#1864 Analysis of mTOR, CXCR4 and PD-1 Checkpoint Pathways in Merkel Cell Neuroendocrine Carcinomas: Correlations with Prognosis and Viral Status

Introduction: Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous neuroendocrine tumor. Prognostic factors currently included in the reference AJCC classification are mainly clinical.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Benhamou J, Deschamps L, Vergier B, Pham-Ledard A, Carlotti A,

Keywords: Merkel cell carcinoma, mTor, CXCR4, PD-L1,

#1680 PD-1, PD-L1 and PD-L2 Expression in Well-Differentiated Small Bowel Gastrointestinal Neuroendocrine Tumours (Wd SB-NETs).

Introduction: Treatment options for patients with advanced Wd SB-NETs are limited.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Lamarca A

Authors: Lamarca A, Nonaka D, Breitwieser W, Ashton G, Barriuso J,

Keywords: immunotherapy,

#1630 The Positive Expression of PD-L1/PD-1 in Gastroenteropancreatic Neuroendocrine Neoplasias Correlates with Prognosis

Introduction: The incidence of Neuroendocrine Neoplasias (NENs) is increasing and their pathological characteristics, varied between races. However, the epidemiology of GEP-NENs in Chinese patients remains poorly characterized especially for the expression of important immune checkpoint protein PD1 and PD-L1.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Yinying W, Chuying W,

Keywords: gastroenteropancreatic neuroendocrine neoplasias, PD-L1, PD-1, immunohistochemistry, prognosis,

#1561 PD1 and PDL1 Expression in Midgut Neuroendocrine Tumors

Introduction: PD1/PDL1 inhibitors have shown promising results in different carcinomas, and correlation between PDL1 expression and response to immunotherapy has been reported. No studies thus far have investigated the expression of PD1 or PDL1 in midgut NETs.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Cives M, Strosberg J, Coppola D,

Keywords: midgut NETs, PD1, PD-L1, lymph node-like structures,

#1268 The Impact of PD-L1 Expression in Patients with Metastatic GEP-NETs

Introduction: Programmed death-ligand 1 (PD-L1), which is expressed on many cancer cells, interacts with PD1 expressed on the surface of T cells, inhibiting the T cells and blocking the antitumor immune response.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Park Y

Authors: Kim S, Park Y,

Keywords: PD-L1, GEP-NETs,