Unanticipated heterogeneity in high-grade large-cell neuroendocrine carcinoma pinpoints cell sub-state specific therapeutic targets

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Introduction: High-grade pancreatic neuroendocrine carcinoma (panNEC) pose challenges in terms of classification and treatment. While molecular genetics have made strides in deciphering significant inter-tumor heterogeneity, the extent of intra-tumoral heterogeneity and lineage plasticity remains unexplored.

Aim(s): We employed a single-nucleus RNA sequencing approach to investigate intra-tumoral heterogeneity, elucidate driving molecular pathways, and identify potentially targetable common cell sub-states.

Materials and methods: We analysed five high-grade panNEC single nuclei transcriptomes, deconstructed the cellular landscape to delineate both shared and unique sub-states that drive tumor pathophysiology and heterogeneous clinical behaviour.

Conference:

Presenting Author:

Authors: Debnath O, Detjen K, Berger H, Kirchner P, Marinoni I,

Keywords: PanNEC, Single cell RNAseq,