#1736
Slit2-Robo1 Signaling Activates Ras to Suppress Metastasis and Is Associated with Time-To-Progression in Pancreatic Neuroendocrine Tumors
Introduction:
Transcriptom analysis revealed that mRNA signatures of distinct metastatic phenotypes in pancreatic NETs (pNETs) exhibit differences in components of the Slit-Robo pathway.
Conference:
14th Annual ENETSConcerence (2017)
Presenting Author:
Authors:
Fischer C,
Göhrig A,
Körner J,
Lombardi M,
Welzel M,
Keywords:
NET,
ras,
slit,
robo,
metastasis,
orthotopic,
#1539
Slit-Robo Signaling Links to Ras Activity to Suppress Metastasis and Is Associated with Time-to-Progression in Pancreatic Neuroendocrine Tumors
Introduction:
mRNA signatures of distinct metastatic phenotypes of pancreatic NETs (pNETs) exhibit differences in several components of the Slit-Robo axon guidance system.
Conference:
13th Annual ENETSConcerence (2016)
Presenting Author:
Fischer C
Authors:
Detjen K,
Göhrig A,
Hilfenhaus G,
Körner J,
Lombardi M,
Keywords:
Slit2,
Robo1,
pancreatic,
NET,
pNET,
metastasis,
mouse model,
#40
Clinical and prognostic implications of the genetic diagnosis of hereditary NET syndromes in asymptomatic patients
Introduction:
Neuroendocrine tumors (NETs) are rare neoplasms, heterogeneous, and with variable biological behavior. NETs can be sporadic or they can arise in complex endocrine hereditary syndromes such as Multiple Endocrine Neoplasias (MEN), Familial Paragangliomatosis (FPGL), Neurofibromatosis type 1 (NF1), von Hippel-Lindau Disease (VHL), Tuberous Sclerosis (TSC) and Carney Complex (CC). By performing genetic screening, patients with hereditary NETs can be identified before the development of tumors.
Conference:
7th Annual ENETSConcerence (2010)
Presenting Author:
Authors:
Faggiano A,
Ramundo V,
Milone F,
Severino R,
Lombardi G,
Keywords:
neuroendocrine tumor,
genetic analysis,
MEN1,
MEN2,
paragangliomatosis,
genotype-phenotype correlation.,
