Abstract Library

#1736 Slit2-Robo1 Signaling Activates Ras to Suppress Metastasis and Is Associated with Time-To-Progression in Pancreatic Neuroendocrine Tumors

Introduction: Transcriptom analysis revealed that mRNA signatures of distinct metastatic phenotypes in pancreatic NETs (pNETs) exhibit differences in components of the Slit-Robo pathway.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Fischer C, Göhrig A, Körner J, Lombardi M, Welzel M,

Keywords: NET, ras, slit, robo, metastasis, orthotopic,

#1539 Slit-Robo Signaling Links to Ras Activity to Suppress Metastasis and Is Associated with Time-to-Progression in Pancreatic Neuroendocrine Tumors

Introduction: mRNA signatures of distinct metastatic phenotypes of pancreatic NETs (pNETs) exhibit differences in several components of the Slit-Robo axon guidance system.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Fischer C

Authors: Detjen K, Göhrig A, Hilfenhaus G, Körner J, Lombardi M,

Keywords: Slit2, Robo1, pancreatic, NET, pNET, metastasis, mouse model,

#770 The Axon Guidance Molecules Slit2 and Robo Control Motility and Growth of Pancreatic Neuroendocrine Tumor Cells

Introduction: Dense vascularization and high frequency of metastasis in pancreatic neuroendocrine tumors (pNET) suggest a central role for the interaction of tumor cells and vessels. Slit2 and its receptors Robo1 and Robo4 act as guidance cues in neurogenesis, angiogenesis and epithelial morphogenesis, and hence represent attractive candidate regulators at the tumor cell/stroma interface.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: Fischer C

Authors: Detjen K, Hilfenhaus G, Göhrig A, Körner J, Welzel M,

Keywords: Axon guidance, Slit2, Robo, NET, metastases, motility,