Abstract Library

#2986 Characterization of 142 Human Pancreatic Neuroendocrine Tumors: ATRX and DAXX Correlation with Clinical-Pathological Data

Introduction: Pancreatic neuroendocrine tumors (PNETs) are rare and heterogeneous neoplasms with a 10-year survival rate less than 30%. Up to 43% of them are driven by inactivating mutations in ATRX or DAXX. These are important players at chromatin remodeling, that when mutated prone cancer cells to initiate the alternative lengthening of telomeres (ALT). ALT phenotype correlates with in situ loss of expression of the proteins ATRX or DAXX and can be corroborated by telomere-FISH.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Gaspar T, Pinheiro J, Canberk S, İnce �, Tokat F,

Keywords: pancreas, pancreatic neuroendocrine tumors, PNETs, ATRX, DAXX, ALT, mosaic,

#1844 Selective Approach in Surgical Treatment of Pancreatic Neuroendocrine Tumors

Introduction: Surgical resection is the main method in treating of pancreatic neuroendocrine tumors (pNETs) . Contemporary perioperative diagnostic can help using selective approaches, to perform organ-preserving (OP) procedures including operations with miniinvasive techniques (MI) such as robot – assisted (RA) or laparoscopic (La).

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Kaldarov A

Authors: Kaldarov A, Kriger A, Berelavichus S, Gorin D, Smirnov A,

Keywords: pancreatic neuroendocrine tumors, surgical treatment, robot, assisted, miniinvasive, laparoscopic,

#1839 Laparoscopic and Robotic Resection for Pancreatic Neuroendocrine Tumors (pNET): Less Is More?

Introduction: Laparoscopy is useful for the resection of pNET, but only a few studies in the Literature describes outcomes for a large series

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: DAMOLI I

Authors: Damoli I, Baroni T, Pollini T, Impellizzeri H, Paiella S,

Keywords: laparoscopic robotic surgery,

#1736 Slit2-Robo1 Signaling Activates Ras to Suppress Metastasis and Is Associated with Time-To-Progression in Pancreatic Neuroendocrine Tumors

Introduction: Transcriptom analysis revealed that mRNA signatures of distinct metastatic phenotypes in pancreatic NETs (pNETs) exhibit differences in components of the Slit-Robo pathway.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Fischer C, Göhrig A, Körner J, Lombardi M, Welzel M,

Keywords: NET, ras, slit, robo, metastasis, orthotopic,

#1539 Slit-Robo Signaling Links to Ras Activity to Suppress Metastasis and Is Associated with Time-to-Progression in Pancreatic Neuroendocrine Tumors

Introduction: mRNA signatures of distinct metastatic phenotypes of pancreatic NETs (pNETs) exhibit differences in several components of the Slit-Robo axon guidance system.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Fischer C

Authors: Detjen K, Göhrig A, Hilfenhaus G, Körner J, Lombardi M,

Keywords: Slit2, Robo1, pancreatic, NET, pNET, metastasis, mouse model,