Bone health in neuroendocrine neoplasms

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Introduction: Neuroendocrine neoplasms (NENs) are a heterogeneous group of rare neoplasms, classified according to localization of the primary tumor, differentiation and grading. The effect of localized or advanced NENs and systemic therapies on bone and muscle health is still controversial.

Aim(s): The aim of this study is to evaluate bone and muscle health in NEN patients.

Materials and methods: A total of 85 patients were enrolled: 38 NEN patients, gastroenteropancreatic and bronchial carcinoid (mean age 70.3 ± 8.4 years), vs 47 healthy controls (CNT) (mean age 69.3 ± 11.8 years). Bone Mineral Density (BMD, g/cm²) and T-score of lumbar spine (L1-L4) and total hip as well as a relative skeletal muscle mass index (RSMI) was calculated using a DXA scan [Lunar full-Prodigy (GE Lunar,Madison,WI,USA); Trabecular bone score (TBS); TBS Insight Medipas Group v 3.0] was derived for each spine DXA examination. Biochemical parameters, disease stage, grading and therapy were collected.

Conference:

Presenting Author:

Authors: Casabella A, Veresani A, Boschetti M, Sulli A, Hasballa I,

Keywords: Bone health, neuroendocrine neoplasm, TBS, RSMI, T-Score,