Abstract Library

#312 Evidence for the role of miR196a in regulating small intestinal neuroendocrine tumor proliferation and metastasis via HOX/AKT pathway activation

Introduction: MicroRNAs (miRNAs) regulate cell proliferation, differentiation, and apoptosis functioning as tumor suppressor genes but their role in NET proliferation and metastasis has not been fully evaluated.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Kidd M, Lawrence B, Alaimo D, Svejda B, Schimmack S,

Keywords: AKT, carcinoid, HOX, miRNA, metastasis, neuroendocrine tumor, proliferation, small intestine,

#309 The Utility of Alpha Internexin as a Predictive Tissue Biomarker for Proliferation in Gastrointestinal and Pancreatic Neuroendocrine Tumors

Introduction: GEP-NETs are increasing but Ki-67 and CgA provide limited information regarding malignancy. A key unmet need is alternative biomarkers to assess the likelihood of local invasion or metastasis.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Schimmack S, Lawrence B, Svejda B, Fischer L, Schmitz-Winnenthal H,

Keywords: alpha-internexin, biomarker, GEP-NET, INA, Ki-67, malignancy, metastasis, neuroendocrine tumor, PCR,

#304 Hepatic Neuroendocrine Tumor Metastasis Proliferation is Hepatocyte Regulated Via a 5HT7 Mediated Induction of an IGF 1 and HGF Feedback Loop Mediated by cAMP, PKA-independent pAKT and pCREB

Introduction: Carcinoid serotonin (5-HT) causes local fibrosis but the effect of 5-HT on hepatocytes has not been established. We hypothesized that tumors and hepatocytes form a metastasis-supportive environment.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Svejda B, Kidd M, Lawrence B, Alaimo D, Schimmack S,

Keywords: 5-HT, carcinoid, growth factor, HGF, IGF-I, hepatocyte, liver, proliferation, neuroendocrine tumor,