Abstract Library

#1572 Study of the Biological Significance of the IGF-IEc (MGF) in Well and Poorly Differentiated Neuroendocrine Neoplasms

Introduction: Insulin-like growth factor-I (IGF-I) has a key role in cell proliferation, differentiation, migration, and survival. Different IGF-I mRNA transcripts, such as IGF-IEc (mechano growth factor, MGF), are produced by alternative splicing. MGF has been implicated in muscle regeneration process as well as in the pathophysiology of various types of cancer.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Alexandraki K

Authors: Alexandraki K, Philippou A, Boutzios G, Theohari I, Moschouris P,

Keywords: Neuroendocrine neoplasms, MGF, IGF-IEc, ki-67,

#430 mTOR Inhibitors Hamper Cell Viability in Selected Human Medullary Thyroid Carcinoma Primary Cultures

Introduction: It has been demonstrated that mTOR inhibitors have potent anti-proliferative effects in a human Medullary Thyroid Carcinoma (MTC) cell line. We here explore the possible role of mTOR inhibitors, Everolimus and BEZ235 (which also inhibits the PI3K pathway) on the effects of Insulin-like Growth Factor-1 (IGF-1) in human MTC primary cultures.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Minoia m, Gentilin E, Rossi M, Tagliati F, Degli Uberti E,

Keywords: mTOR inhibitors, IGF-1, MTC,

#304 Hepatic Neuroendocrine Tumor Metastasis Proliferation is Hepatocyte Regulated Via a 5HT7 Mediated Induction of an IGF 1 and HGF Feedback Loop Mediated by cAMP, PKA-independent pAKT and pCREB

Introduction: Carcinoid serotonin (5-HT) causes local fibrosis but the effect of 5-HT on hepatocytes has not been established. We hypothesized that tumors and hepatocytes form a metastasis-supportive environment.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Svejda B, Kidd M, Lawrence B, Alaimo D, Schimmack S,

Keywords: 5-HT, carcinoid, growth factor, HGF, IGF-I, hepatocyte, liver, proliferation, neuroendocrine tumor,

#269 Expression of IGF/mTOR Pathway Components in Human Pheochromocytomas and In Vitro Inhibition of PC12 Rat Pheochromocytoma Cell Growth by mTOR Inhibitors

Introduction: The pathogenesis of pheochromocytomas (pheo) is poorly understood and malignant pheo need new treatment options. mTOR inhibitors, as sirolimus(S) and everolimus(E), are promising antineoplastic drugs.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: De Martino M, Feelders R, van Koetsveld P, De Krijger R, Sprij-Mooij D,

Keywords: IGF, mTOR, everolimus, sirolimus, pheochromocytomas, PC12, adrenal, neuroendocrine, tumor,

#266 Everolimus Reduces Cell Viability in Selected Human Medullary Thyroid Carcinoma Primary Cultures

Introduction: It has been demonstrated that everolimus, an mTOR inhibitor, has a potent anti-proliferative effect in a human Medullary Thyroid Carcinoma (MTC) cell line, TT, and in two human MTC primary cultures.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Minoia M, Filieri C, Tagliati F, Buratto M, Ambrosio M,

Keywords: medullary thyroid cancer, everolimus, mTOR, antiproliferative effects,