Abstract Library

#1040 TIM16 Inhibition Decreases Calcitonin Secretion and Enhances Sensitivity to Paclitaxel in a Human Medullary Thyroid Carcinoma Cells

Introduction: TIM 16 protein is part of the traslocase complex TIM 23 situated in the mitochondrial inner membrane, encoded by the Magmas gene, that is overexpressed in several tumors. Magmas silencing causes a greater sensitivity to apoptotic stimuli. We recently demonstrated that, in a human medullary thyroid carcinoma cell line (TT), compound 5, a TIM 16 inhibitor, was not cytotoxic but enhanced the proapoptotic effects of staurosporine

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Gagliano T, Riva E, Tagliati F, Matteotti D, Brugnoli V,

Keywords: TIM16, Magmas, Paclitaxel, Calcitonin, Medullary Thyroid Carcinoma,

#986 Expression of the Truncated Somatostatin Receptor Variant Sstr5TMD4 in Medullary Thyroid Carcinoma

Introduction: Medullary thyroid carcinoma (MTC) is a rare tumor originating from thyroid parafollicular C cell. The only available treatment is surgical resection, which is not always feasible. Somatostatin and its receptors are expressed both in normal human thyroid C cells and in MTC, but their role has not been fully elucidated. The discovery of a truncated isoform of Sstr5, Sstr5TMD4, associated with increased invasiveness and aggressiveness in breast cancer, has opened new insight in the role of Sstr in cancers.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Zatelli M

Authors: Molè D, Gahete M, Gagliano T, Tagliati F, Castano J,

Keywords: MTC, SSTR5TMD4,

#430 mTOR Inhibitors Hamper Cell Viability in Selected Human Medullary Thyroid Carcinoma Primary Cultures

Introduction: It has been demonstrated that mTOR inhibitors have potent anti-proliferative effects in a human Medullary Thyroid Carcinoma (MTC) cell line. We here explore the possible role of mTOR inhibitors, Everolimus and BEZ235 (which also inhibits the PI3K pathway) on the effects of Insulin-like Growth Factor-1 (IGF-1) in human MTC primary cultures.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Minoia m, Gentilin E, Rossi M, Tagliati F, Degli Uberti E,

Keywords: mTOR inhibitors, IGF-1, MTC,

#266 Everolimus Reduces Cell Viability in Selected Human Medullary Thyroid Carcinoma Primary Cultures

Introduction: It has been demonstrated that everolimus, an mTOR inhibitor, has a potent anti-proliferative effect in a human Medullary Thyroid Carcinoma (MTC) cell line, TT, and in two human MTC primary cultures.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Minoia M, Filieri C, Tagliati F, Buratto M, Ambrosio M,

Keywords: medullary thyroid cancer, everolimus, mTOR, antiproliferative effects,

#265 A Novel PKCßII Inhibitor Induces Antiproliferative Effects in Human Pancreatic Neuroendocrine Tumor Cells

Introduction: Deregulation of the protein kinase C (PKC) signaling pathway has been implicated in tumor progression.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Molè D, Gagliano T, Gentilin E, Bondanelli M, Tagliati F,

Keywords: PKCßII, selective inhibitor, human pancreatic neuroendocrine cell line,